One measurement fixes the whole hexagon, because every other measurement is a fixed multiple of the side. The circumradius, the distance from the center to a corner, equals the side length exactly. A hexagon with side 4 fits inside a circle of radius 4, which is a property no other regular polygon shares.
The long diagonal runs from one corner through the center to the opposite corner, so it is 2s. The short diagonal runs from the middle of one side to the middle of the opposite side, so it is s x sqrt(3). For side 4, the diagonals are 8 and 6.93. The short diagonal is also called the across flats width, and it is the number stamped on hex bolt heads and socket sizes.
The apothem is half the short diagonal. It is the distance from the center to the middle of a side, and it is the height of each of the six equilateral triangles. The area can also be written as half the perimeter times the apothem, which gives the same answer. For side 4, half of 24 times 3.4641 is 41.57.